NFL Week 6 Predictions: Can the Chiefs and Patriots Avoid Upsets?
Journey Tribune – As the NFL season hits Week 6, the league’s balance of power feels more uncertain than ever. The early favorites are facing turbulence, while underdogs are finding new life. With big names like the Chiefs, Eagles, and Patriots all vulnerable, this week could mark a turning point in the 2025 campaign.
NFL.com analysts Ali Bhanpuri, Brooke Cersosimo, Dan Parr, Gennaro Filice, and Tom Blair have shared their insights on each matchup. Here’s a fresh look at the biggest storylines and predictions heading into Week 6.
Thursday Night Football: Eagles vs. Giants – Philly Looks to Rebound
The Philadelphia Eagles (4–1) head to MetLife Stadium to face the struggling New York Giants (1–4). Despite Philadelphia’s recent stumble, the talent gap here is enormous.
Tom Blair notes that the Giants’ rookie quarterback Jaxson Dart has brought some new energy, but the Eagles’ roster is still vastly superior. Injuries to Landon Dickerson and Jalen Carter could make things interesting, but Jalen Hurts and his offense should do enough to survive a gritty divisional matchup.
Prediction: Eagles 24, Giants 18.
Broncos vs. Jets in London – Bo Nix Takes the Stage
Across the Atlantic, the Denver Broncos (3–2) meet the winless New York Jets (0–5) at Tottenham Hotspur Stadium. Denver is coming off a massive upset over the defending Super Bowl champs — and confidence is sky-high.
Brooke Cersosimo praises Sean Payton’s defense, which ranks second in scoring defense and leads the NFL in sacks. Rookie QB Bo Nix continues to grow within the system, while the Jets are still searching for an offensive identity.
Even with the trip overseas, the Broncos look like the more complete team.
Prediction: Broncos 28, Jets 20.
Rams vs. Ravens – Two Teams on Opposite Paths
The Los Angeles Rams (3–2) visit Baltimore (1–4) in a matchup that feels lopsided. The Rams’ high-powered offense ranks near the top of the league, while the Ravens’ defense sits near the bottom.
Without Lamar Jackson, Baltimore’s attack lacks explosiveness. Derrick Henry hasn’t looked like himself, and Gennaro Filice points out that the Rams haven’t allowed a 100-yard rusher all season. Expect another dominant performance from Sean McVay’s squad.
Prediction: Rams 30, Ravens 17.
Cowboys vs. Panthers – Dak’s Time to Shine
In Charlotte, the Dallas Cowboys (2-2-1) meet the Carolina Panthers (2–3) in what could become a shootout.
Ali Bhanpuri highlights how Dak Prescott and the Cowboys’ passing game have started to click again. While Dallas’ run defense has been shaky, its aerial attack should be the difference-maker against a Carolina defense that’s struggled in recent weeks.
Expect big plays, plenty of points, and another step forward for Dallas’ offense.
Prediction: Cowboys 31, Panthers 24.
Colts vs. Cardinals – Indy’s Quiet Dominance Continues
Few teams have been more quietly impressive than the Indianapolis Colts (4–1). Their balanced offense and consistent defense have propelled them to one of the AFC’s best records.
Meanwhile, the Arizona Cardinals (2–3) continue to implode late in games, losing three straight by a combined five points. Tom Blair believes the Colts’ stability and leadership under Shane Steichen will be too much for Kyler Murray and company to handle.
Prediction: Colts 29, Cardinals 18.
Seahawks vs. Jaguars – Road Warriors vs. Opportunists
The Seattle Seahawks (3–2) have become road warriors under coach Mike Macdonald, boasting eight straight road wins. But this week’s test in Jacksonville (4–1) won’t be easy.
The Jaguars lead the NFL in takeaways and are fresh off an emotional comeback victory over the Chiefs. Gennaro Filice warns that Seattle must protect the ball if it wants to keep its streak alive. Expect a tight battle between two playoff-caliber teams.
Prediction: Seahawks 27, Jaguars 23.
Patriots vs. Saints – Momentum on the Line
Both the New England Patriots (3–2) and New Orleans Saints (1–4) are coming off emotional wins. Ali Bhanpuri believes the Patriots’ recent victory over Buffalo could be a turning point.
While Spencer Rattler continues to grow in Kellen Moore’s system, the Saints need more aggressiveness downfield. The Patriots’ defense should make enough plays to escape with another close win.
Prediction: Patriots 25, Saints 20.
49ers vs. Buccaneers – Baker Mayfield’s Moment
Baker Mayfield is thriving in Tampa Bay. The Buccaneers (4–1) are one of the NFC’s most surprising teams, and their chemistry under Todd Bowles has been undeniable.
The San Francisco 49ers (4–1) are still dangerous, but their injury issues and lack of depth make them vulnerable. Tom Blair believes Mayfield’s confidence and Tampa’s home-field advantage will tilt this one their way.
Prediction: Buccaneers 26, 49ers 22.
Lions vs. Chiefs – A Sunday Night Blockbuster
The game of the week features the Detroit Lions (4–1) visiting the Kansas City Chiefs (2–3). The Lions have looked like the NFL’s most complete team for a month, while the Chiefs are desperate to regain form after a tough loss in Jacksonville.
Dan Parr expects Patrick Mahomes and his offense to keep improving, especially with the return of wide receiver Xavier Worthy. Detroit’s defense has been sharp, but Kansas City’s home-field advantage and urgency could make the difference.
Prediction: Chiefs 30, Lions 28.
Final Thoughts: The Season Starts to Take Shape
By Week 6, every team begins to reveal its true identity. The Broncos and Rams are surging, the Chiefs are fighting to stay relevant, and young squads like Seattle and Indianapolis are starting to look dangerous.
If this week has taught us anything, it’s that the NFL’s balance of power can shift in an instant — and every Sunday writes a new chapter in a season full of surprises.
